Title of article
Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors
Author/Authors
Nan-Horng Lin، نويسنده , , Ping Xia، نويسنده , , Peter Kovar، نويسنده , , Chang Park، نويسنده , , Zehan Chen، نويسنده , , Haiying Zhang، نويسنده , , Saul H. Rosenberg، نويسنده , , Hing L. Sham، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
421
To page
426
Abstract
Chk1 inhibitors have emerged as a novel class of neoplastic agents for abrogating the G2 DNA damage checkpoint arrest. Analogs of the Chk1 inhibitor, 3-ethylidene-1,3-dihydro-indol-2-one, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 28, which possesses potent enzymatic and cellular activities.
Keywords
inhibitor , kinase , Checkpoint 1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796389
Link To Document