Title of article
Metalloantimalarials: Synthesis, X-ray crystal structure of potent antimalarial copper (II) complex of arylazo-4-hydroxy-1,2-naphthoquinone
Author/Authors
Nikhil H. Gokhale، نويسنده , , K. Shirisha، نويسنده , , Subhash B. Padhye، نويسنده , , Simon L. Croft، نويسنده , , Howard D. Kendrick، نويسنده , , Vickie Mckee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
430
To page
432
Abstract
The crystal structure of copper (II) complex of 3-arylazo-4-hydroxy-1,2-naphthoquinone is reported. The in vitro antimalarial activity of analogous compounds against Plasmodium falciparum 3D7 strain reveals correlation with metal redox couple, suggesting component of parasitic electron transport chain as a possible target.
Keywords
antimalarial activity , Copper complexes , Hydroxynaphthoquinone , metal complexation , X-ray structure
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796391
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