Title of article
PTP-1B inhibitors: Cyclopenta[d][1,2]-oxazine derivatives
Author/Authors
Sung Yun Cho، نويسنده , , Ji Yoen Baek، نويسنده , , Sang Sub Han، نويسنده , , Seung Kyu Kang، نويسنده , , Jae Du Ha، نويسنده , , Jin-Hee Ahn، نويسنده , , Jae Don Lee، نويسنده , , Kwang Rok Kim، نويسنده , , Hyae Gyeong Cheon، نويسنده , , Sang Dal Rhee، نويسنده , , Sung-Don Yang، نويسنده , , Gyu Hwan Yon، نويسنده , , Chwang Siek Pak، نويسنده , , Joong-Kwon Choi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
499
To page
502
Abstract
A series of novel cyclopenta[d][1,2]-oxazine derivatives was prepared and evaluated for their inhibitory activity toward protein tyrosine phosphatase 1B (PTP-1B). Compound 6s was found to be an inhibitor of PTP-1B with nanomolar IC50 value and high level of selectivity over other recombinant phosphatases.
Keywords
2]-oxazine , PTP-1B , Diabetes , inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796403
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