Title of article
Synthesis and biological evaluation of gem-diamine 1-N-iminosugars related to l-iduronic acid as inhibitors of heparan sulfate 2-O-sulfotransferase
Author/Authors
Jillian R. Brown، نويسنده , , Yoshio Nishimura، نويسنده , , Jeffrey D. Esko، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
532
To page
536
Abstract
A variety of gem-diamine 1-N-iminosugars related to l-iduronic acid were synthesized and evaluated as inhibitors of heparan sulfate uronyl 2-O-sulfotransferase using an in vitro enzyme assay. Two iminosugars containing guanidino groups acted as potent in vitro inhibitors of the enzyme.
Keywords
Iminosugars , Glycosyltransferase , inhibitors , Heparan sulfate , Synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796410
Link To Document