Title of article
Sulfamoyl-4-oxoquinoline-3-carboxamides: Novel potentiators of defective ΔF508-cystic fibrosis transmembrane conductance regulator chloride channel gating
Author/Authors
Yat Fan Suen، نويسنده , , Lori Robins، نويسنده , , Baoxue Yang، نويسنده , , A.S. Verkman، نويسنده , , Michael H. Nantz، نويسنده , , Mark J. Kurth، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
537
To page
540
Abstract
The synthesis of a small collection of sulfamoyl-4-oxoquinoline-3-carboxamides is described for use as correctors of defective gating of the ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Several compounds with submicromolar potency were obtained. N-Ethyl 6-(ethylphenylsulfamoyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (7b) was found to be the most effective sulfonamide corrector of defective ΔF508-CFTR gating.
Keywords
cystic fibrosis , CFTR , Activator , Potentiator , Sulfonamide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796411
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