Title of article
Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase
Author/Authors
Juliana Ruiz-Caro، نويسنده , , Aravind Basavapathruni، نويسنده , , Joseph T. Kim، نويسنده , , Christopher M. Bailey، نويسنده , , Ligong Wang، نويسنده , , Karen S. Anderson، نويسنده , , Andrew D. Hamilton، نويسنده , , William L. Jorgensen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
668
To page
671
Abstract
Following computational analyses, potential non-nucleoside inhibitors of HIV-1 reverse transcriptase have been pursued through synthesis and assaying for anti-viral activity. The general class Het–NH–Ph–U has been considered, where Het is an aromatic heterocycle and U is an unsaturated, hydrophobic group. Results for compounds with Het = 2-thiazoyl and 2-pyrimidinyl are the focus of this report.
Keywords
NNRTI , Diarylamine , Computer-aided drug design , Anti-HIV drug , Pyrimidinylamine , Thiazoylamine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796437
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