Title of article
Generation of potent coagulation protease inhibitors utilizing zinc-mediated chelation
Author/Authors
Wendy B. Young، نويسنده , , Paul Sprengeler، نويسنده , , William D. Shrader، نويسنده , , Yong Li، نويسنده , , Roopa Rai، نويسنده , , Erik Verner، نويسنده , , Thomas Jenkins، نويسنده , , Paul Fatheree، نويسنده , , Aleksandr Kolesnikov، نويسنده , , James W. Janc، نويسنده , , Lynne Cregar، نويسنده , , Kyle Elrod، نويسنده , , Brad Katz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
710
To page
713
Abstract
Inhibition of coagulation proteases such as thrombin, fXa, and fVIIa has been a focus of ongoing research to produce safe and effective antithrombotic agents. Herein, we describe a unique zinc-mediated chelation strategy to streamline the discovery of potent inhibitors of fIIa, fXa, and fVIIa. SAR studies that led to the development of selective inhibitors of fXa will also be detailed.
Keywords
Zinc chelation , Factor Xa , factor VIIa , protease inhibitor , coagulation , thrombin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796446
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