Title of article
Naphthofuroquinone derivatives: Inhibition of receptor tyrosine kinases
Author/Authors
Kee-In Lee، نويسنده , , Youmie Park، نويسنده , , Su-Jin Park، نويسنده , , Jung-Hwan Hwang، نويسنده , , Sung-Jin Lee، نويسنده , , Gun-Hee Kim، نويسنده , , Woo-Kyu Park، نويسنده , , Sunghou Lee، نويسنده , , Daeyoung Jeong، نويسنده , , Jae Yang Kong، نويسنده , , Hee-Kyoung Kang، نويسنده , , HeeYeong Cho، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
737
To page
742
Abstract
A series of dinaphtho[1,2-b;2′,3′-d]furan-7,12-dione derivatives were synthesized and evaluated for inhibitory activities against receptor tyrosine kinases. The naphthofuroquinone compounds with dialkylaminoethoxy group at C(5)-position (7, 8, 10, and 11) manifested strong inhibitory activities against epidermal growth factor receptor and vascular endothelial growth factor receptor. Docking study of 11 with EGFR was also performed.
Keywords
Naphthofuroquinone , Receptor tyrosine kinase , Docking study
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796452
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