Author/Authors :
Kee-In Lee، نويسنده , , Youmie Park، نويسنده , , Su-Jin Park، نويسنده , , Jung-Hwan Hwang، نويسنده , , Sung-Jin Lee، نويسنده , , Gun-Hee Kim، نويسنده , , Woo-Kyu Park، نويسنده , , Sunghou Lee، نويسنده , , Daeyoung Jeong، نويسنده , , Jae Yang Kong، نويسنده , , Hee-Kyoung Kang، نويسنده , , HeeYeong Cho، نويسنده ,
Abstract :
A series of dinaphtho[1,2-b;2′,3′-d]furan-7,12-dione derivatives were synthesized and evaluated for inhibitory activities against receptor tyrosine kinases. The naphthofuroquinone compounds with dialkylaminoethoxy group at C(5)-position (7, 8, 10, and 11) manifested strong inhibitory activities against epidermal growth factor receptor and vascular endothelial growth factor receptor. Docking study of 11 with EGFR was also performed.
