Two methylene groups in phospholipids distinguish between apoptosis and necrosis for tumor cells

High inhibitory effects of hybrid liposomes (HL) themselves composed of DMPC/10 mol % C12(EO)23 on the growth of HL-60 cells were obtained without any drug. Induction of apoptosis was obtained by the HL of DMPC/10 mol % C12(EO)23. On the other hand, necrosis was observed for the HL of DLPC/10 mol % C12(EO)23. In the case of DPPC/10 mol % C12(EO)23, neither apoptosis nor necrosis was observed.