Title of article
Synthesis and structure–activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists
Author/Authors
Christopher G. Thomson، نويسنده , , Emma Carlson، نويسنده , , Gary G. Chicchi، نويسنده , , Janusz J. Kulagowski، نويسنده , , Marc M. Kurtz، نويسنده , , Christopher J. Swain، نويسنده , , Kwei-Lan C. Tsao، نويسنده , , Alan Wheeldon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
811
To page
814
Abstract
A series of 8-azabicyclo[3.2.1]octane amine hNK1 antagonists has been investigated and structure–activity relationships of the benzylamine and 6-exo substituents described. Acidic substituents at C6 give a series of high affinity compounds for hNK1 with selectivity over the hERG channel.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796466
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