Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands
Author/Authors :
Joseph P. Sabatucci، نويسنده , , Mark A. Ashwell، نويسنده , , Eugene Trybulski، نويسنده , , Mary-Margaret O’Donnell، نويسنده , , William J. Moore، نويسنده , , Douglas C. Harnish، نويسنده , , Christopher C. Chadwick، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
5
From page :
854
To page :
858
Abstract :
The transcription factor nuclear factor-κB (NF-κB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-κB transcriptional activity but are devoid of conventional estrogenic activity.
