Title of article
Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands
Author/Authors
Joseph P. Sabatucci، نويسنده , , Mark A. Ashwell، نويسنده , , Eugene Trybulski، نويسنده , , Mary-Margaret O’Donnell، نويسنده , , William J. Moore، نويسنده , , Douglas C. Harnish، نويسنده , , Christopher C. Chadwick، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
854
To page
858
Abstract
The transcription factor nuclear factor-κB (NF-κB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-κB transcriptional activity but are devoid of conventional estrogenic activity.
Keywords
Nuclear factor-?B , estrogen receptor , Sulfonamide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796475
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