Title of article
Synthesis and reactivity with β-lactamases of a monobactam bearing a retro-amide side chain
Author/Authors
S.A. Adediran، نويسنده , , J.-F. Lohier، نويسنده , , D. Cabaret، نويسنده , , M. Wakselman، نويسنده , , R.F. Pratt، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
869
To page
871
Abstract
The monobactam sodium 3-benzylcarbamoyl-2-oxo-1-azetidinesulfonate, bearing a retro (vs classical β-lactam)-amide side chain, has been synthesized and the kinetics of its reaction with typical β-lactamases studied. The new compound is generally a poorer substrate than the analogous compound with a normal side chain but its formation of a transiently stable complex with a class C β-lactamase sustains the retro-amide side-chain concept.
Keywords
?-Lactam , antibiotic , ?-lactamase , enzyme , Retro-amide , Kinetics
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796478
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