Title of article
Design and total synthesis of a fluorescent phorboxazole a analog for cellular studies
Author/Authors
Jiehao Chen، نويسنده , , Lu-ying Yang، نويسنده , , T. Matthew Hansen، نويسنده , , Mary M. Engler، نويسنده , , Chi Sing Lee، نويسنده , , James J. La Clair، نويسنده , , Craig J. Forsyth، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
901
To page
904
Abstract
To enable studies to elucidate the intracellular processing and targeting of the potent cytostatic/apoptotic anticancer natural products phorboxazoles A and B, a fluorescent derivative has been developed. This involved the total syntheses of the terminal alkyne 33-O-Me-45,46-dehydrobromophorboxazole A (MDHBPA) and a terminal vinyl iodide derivative of the blue fluorescent dye N,N,-dimethyl-7-aminocoumarin (DMC). Sonogashira coupling of these partners provided enyne DMC–MDHBPA in high yield.
Keywords
Phorboxazole , probe , anticancer , total synthesis , coumarin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796486
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