Title of article
Synthesis of 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent
Author/Authors
Vandana Srivastava، نويسنده , , Arvind S. Negi، نويسنده , , J.K. Kumar، نويسنده , , Uzma Faridi، نويسنده , , Brijesh S. Sisodia، نويسنده , , M.P. Darokar، نويسنده , , Suaib Luqman، نويسنده , , S.P.S. Khanuja، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
911
To page
914
Abstract
3′,4′,5′-Trimethoxy benzoyl-naphthalene 2-O-acetic acid (5) underwent base catalysed intramolecular condensation to yield exclusively 1-(3′,4′,5′-trimethoxy) phenyl naphtho[2,1-b]furan 8. The cyclised product 8 has been characterised by spectroscopy. The product 8 showed significant anticancer activity against human cancer cell lines COLO320DM (colon), CaCO2 (colon) and WRL68 (liver) at 0.7, 0.65 and 0.50 μg/ml concentrations, respectively, in the in vitro MTT assay.
Keywords
Gallic acid , Intramolecular condensation , HMQC , anticancer , MTT assay , Aryl naphthofurans
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796488
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