Title of article
Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists
Author/Authors
Ying Lu، نويسنده , , Zongru Guo، نويسنده , , Yanshen Guo، نويسنده , , Jun Feng، نويسنده , , Fengming Chu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
915
To page
919
Abstract
A series of 2-alkoxydihydrocinnamates were synthesized as PPARγ and PPARα dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPARα/γ dual agonist and will be further evaluated for the treatment of type II diabetes.
Keywords
Antidiabetes , 2-Alkoxydihydrocinnamates , PPAR agonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796489
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