Title of article
Phenolic P2/P3 core motif as thrombin inhibitors—Design, synthesis, and X-ray co-crystal structure
Author/Authors
Stephen Hanessian، نويسنده , , Eric Therrien، نويسنده , , Willem A.L. van Otterlo، نويسنده , , Malken Bayrakdarian، نويسنده , , Ingemar Nilsson، نويسنده , , Ola Fjellstr?m، نويسنده , , Yafeng Xue، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1032
To page
1036
Abstract
Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions.
Keywords
thrombin , Trypsin , phenol , inhibitor , Sulfonamide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796512
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