Title of article :
Phenolic P2/P3 core motif as thrombin inhibitors—Design, synthesis, and X-ray co-crystal structure
Author/Authors :
Stephen Hanessian، نويسنده , , Eric Therrien، نويسنده , , Willem A.L. van Otterlo، نويسنده , , Malken Bayrakdarian، نويسنده , , Ingemar Nilsson، نويسنده , , Ola Fjellstr?m، نويسنده , , Yafeng Xue، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions.
Keywords :
thrombin , Trypsin , phenol , inhibitor , Sulfonamide
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
