Author/Authors :
Adri van den Hoogenband، نويسنده , , Jan H. van Maarseveen، نويسنده , , Andrew C. McCreary، نويسنده , , Arie T. Mulder، نويسنده , , Guus J.M. van Scharrenburg، نويسنده , , Herman H. van Stuivenberg، نويسنده , , Theo J.J. Zethof، نويسنده , , Barbara Zijta، نويسنده , , Wouter I. Iwema Bakker، نويسنده ,
Abstract :
The synthesis and structure–activity relations for a new class of centrally active NK-1 receptor antagonists are described. The new compounds are based on piperazine 2 and contain an oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay.
Keywords :
Neurokinin , Oxime ethers , SAR , synthesis
