Title of article :
Pyridazines part 41: Synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones
Author/Authors :
Abel Crespo، نويسنده , , Caroline Meyers، نويسنده , , Alberto Coelho، نويسنده , , Matilde Y??ez، نويسنده , , Nuria Fraiz، نويسنده , , Eddy Sotelo، نويسنده , , Bert U.W. Maes، نويسنده , , Reyes Laguna، نويسنده , , Ernesto Cano، نويسنده , , Guy L.F. Lemière، نويسنده , , Enrique Ravi?a، نويسنده ,
Abstract :
As part of the optimization process of the lead compound I a focussed library of diversely substituted pyridazin-3(2H)-ones containing a 3-oxo-3-phenylprop-1-en-1-yl or 3-phenylprop-2-enoyl fragment at position 5 has been obtained and evaluated as antiplatelet agents. The structural modification at positions 2, 6 and 4 of the heterocyclic moiety allowed us to obtain preliminary information on the structure–activity relationship in this family.
Keywords :
Palladium , Platelets , pyridazinones , antiplatelet agents
