Title of article
Structure–activity relationships of α-amino acid ligands for the α2δ subunit of voltage-gated calcium channels
Author/Authors
Kathleen H. Mortell، نويسنده , , David J. Anderson، نويسنده , , James J. Lynch III، نويسنده , , Sherry L. Nelson، نويسنده , , Kathy Sarris، نويسنده , , Heath McDonald، نويسنده , , Reza Sabet، نويسنده , , Scott Baker، نويسنده , , Prisca Honore، نويسنده , , Chih-Hung Lee، نويسنده , , Michael F. Jarvis، نويسنده , , Murali Gopalakrishnan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1138
To page
1141
Abstract
A series of α-amino acids were identified as ligands which compete with gabapentin for binding to the α2δ subunit of voltage-dependent Ca2+ channels. Potent analogs were identified. Their activity in an in vivo pain assay is described.
Keywords
?2? , Voltage-gated calcium channel , amino acids , Gabapentin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796530
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