Title of article
Antimicrobial β-peptoids by a block synthesis approach
Author/Authors
Steven W. Shuey، نويسنده , , William J. Delaney، نويسنده , , Mukesh C. Shah، نويسنده , , Mark A. Scialdone، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1245
To page
1248
Abstract
Antimicrobial peptides and their mimetics offer a potential new disinfective tool. β-Peptoids (oligo-N-substituted β-alanines) were synthesized and investigated for antimicrobial activity. A block approach whereby di- and tri-β-peptoids were first prepared and then ligated via amide bond formation to synthesize larger β-peptoids was developed. The β-peptoids were found to possess moderate activity in an Escheridchia coli assay.
Keywords
Antimicrobial , ?-Peptoid , Peptide mimetic
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796553
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