Author/Authors :
Geoffrey A. McKay، نويسنده , , S. Ranga Reddy and P. Manikyamba، نويسنده , , Francis Arhin، نويسنده , , Adam Belley، نويسنده , , Dario Lehoux، نويسنده , , Greg Moeck، نويسنده , , Ingrid Sarmiento، نويسنده , , Thomas R. Parr، نويسنده , , Philippe Gros، نويسنده , , Jerry Pelletier، نويسنده , , Adel Rafai Far، نويسنده ,
Abstract :
Screening of a chemical library in a DNA helicase assay involving the Pseudomonas aeruginosa DnaB helicase provided a triaminotriazine inhibitor with good antibacterial activity but associated cytotoxicity toward mammalian cells. Synthesis of analogs provided a few inhibitors that retained antibacterial activity and demonstrated a significant reduction in cytotoxicity. The impact of serum and initial investigations toward a mode of action highlight several features of this class of compounds as antibacterials.
