Title of article :
Synthesis and biological evaluation of simplified mycothiazole analogues
Author/Authors :
Graciela Mahler، نويسنده , , Gloria Serra، نويسنده , , Sylvia Dematteis، نويسنده , , Jenny Salda?a، نويسنده , , Laura Dom?nguez، نويسنده , , Eduardo Manta، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L4 larvae of nematode Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity.
Keywords :
Mycothiazole , Oxazolines , anthelmintic , HTC-15 colon cells , Thiazolines , Deoxo-Fluor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
