Author/Authors :
Julieta Coro، نويسنده , , Richard Atherton، نويسنده , , Susan Little، نويسنده , , Hayley Wharton، نويسنده , , Vanessa Yardley، نويسنده , , Amaury Alvarez Jr.، نويسنده , , Margarita S?arez، نويسنده , , Rolando Pérez، نويسنده , , Hortensia Rodr?guez، نويسنده ,
Abstract :
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b. rhodesiense with IC50 values ranging between 0.3 and 4 μM for the most active compounds.
