Title of article
From pyrroles to pyrrolo[1,2-a]pyrazinones: A new class of mGluR1 antagonists
Author/Authors
Fabrizio Micheli، نويسنده , , Paolo Cavanni، نويسنده , , Romano Di Fabio، نويسنده , , Carla Marchioro، نويسنده , , Daniele Donati، نويسنده , , Stefania Faedo، نويسنده , , Micaela Maffeis، نويسنده , , Fabio Maria Sabbatini، نويسنده , , Maria Elvira Tranquillini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1342
To page
1345
Abstract
Exploiting the SAR of the known pyrrole derivatives, a new class of mGluR1 antagonists was developed through a cyclization of the C-2 position on the pyrrole N-1 nitrogen. The resulting pyrrolo[1,2-a]pyrazinones are potent and noncompetitive antagonists.
Keywords
mGluR1 , pyrrole , Antagonist , Excitatory amino acids , Metabotropic
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796574
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