Title of article
Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents
Author/Authors
M.P.S. Ishar، نويسنده , , Gurpinder Singh، نويسنده , , Satyajit Singh، نويسنده , , K.K. Sreenivasan، نويسنده , , Gurmit Singh Pahal، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1366
To page
1370
Abstract
6-Chloro-2-pyrrolidino-/morpholino-/piperidino-/N-methylpiperazino-3-formyl-chromones (13–16) and 6-fluoro-2,7-di-morpholino-/piperidino-/N-methylpiperazino-3-formylchromones (17–19) have been synthesized as potential topoisomerase inhibitor anticancer agents, and evaluated, in vitro, against Ehrlich ascites carcinoma (EAC) cells, and also in vivo on EAC bearing mice. The compounds displayed promising anticancer activity under these test systems and shall serve as useful ‘leads’ for further design.
Keywords
Topoisomerase inhibitors , antitumor , DNA topoisomerases , Chromone , Anticancer
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796580
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