Author/Authors :
Christopher G. Thomson، نويسنده , , Karen Duncan، نويسنده , , Stephen R. Fletcher، نويسنده , , Ian T. Huscroft، نويسنده , , Gopalan Pillai، نويسنده , , Piotr Raubo، نويسنده , , Alison J. Smith، نويسنده , , Darren Stead، نويسنده ,
Abstract :
A series of sarcosine based indandione hGlyT1 inhibitors has been developed. Optimization of substitution around the indandione and sarcosine moieties has led to highly potent inhibitors at hGlyT1, which show selectivity over a number of other receptors.
Keywords :
Sarcosine , Potent , Selectivity , GlyT1 inhibitors , Indandione
