Author/Authors :
Long Cui، نويسنده , , MinKyun Na، نويسنده , , Hyuncheol Oh، نويسنده , , Eun Young Bae، نويسنده , , Dae Gwin Jeong، نويسنده , , Seong-Eon Ryu، نويسنده , , Sohee Kim، نويسنده , , Bo Yeon Kim، نويسنده , , Won Keun Oh، نويسنده , , Jong Seog Ahn، نويسنده ,
Abstract :
An organic layer prepared from the Chinese crude drug ‘Sang-Bai-Pi’ (Morus root bark) was studied in order to identify the inhibitory compounds for protein tyrosine phosphatase 1B (PTP1B). Bioassay-guided fractionation resulted in the isolation of sanggenon C (1), sanggenon G (2), mulberrofuran C (3) and kuwanon L (4) as PTP1B inhibitors, along with moracin O (5) and moracin P (6). Compounds 1–4 inhibited PTP1B with IC50 values ranging from 1.6 ± 0.3 μM to 16.9 ± 1.1 μM.
Keywords :
Morus root bark , Protein tyrosine phosphatase 1B , Sanggenon C , Sanggenon G , Kuwanon L , Mulberrofuran C
