Cyclodextrin-grafted polysaccharides as supramolecular carrier systems for naproxen

Dextran, mannan and carboxymethylcellulose, previously activated by periodate oxidation, were grafted with β-cyclodextrin moieties by reductive alkylation in the presence of sodium borohydride. These polymers were used as supramolecular carriers for naproxen, improving the ‘in vivo’ anti-inflammatory properties of this drug.