Title of article
Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3
Author/Authors
Brian E. Fink، نويسنده , , Ashvinikumar V. Gavai، نويسنده , , John S. Tokarski، نويسنده , , Bindu Goyal، نويسنده , , Raj Misra، نويسنده , , Hai-yun Xiao، نويسنده , , S. David Kimball، نويسنده , , Wen-Ching Han، نويسنده , , Derek Norris، نويسنده , , Thomas E. Spires، نويسنده , , Dan You، نويسنده , , Marco M. Gottardis، نويسنده , , Matthew V. Lorenzi، نويسنده , , Gregory D. Vite، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1532
To page
1536
Abstract
A novel series of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17β-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays.
Keywords
17?-HSD3 , Hydroxysteroid dehydrogenase , Tetrahydrodibenzazocine , prostate cancer , androstenedione
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796614
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