Title of article
Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists
Author/Authors
Martin C. Clasby، نويسنده , , Samuel Chackalamannil، نويسنده , , Michael Czarniecki، نويسنده , , Dario Doller، نويسنده , , Keith Eagen، نويسنده , , William J. Greenlee، نويسنده , , Yan Lin، نويسنده , , Hsingan Tsai، نويسنده , , Yan Xia، نويسنده , , Ho-Sam Ahn، نويسنده , , Jacqueline Agans-Fantuzzi، نويسنده , , George Boykow، نويسنده , , Madhu Chintala، نويسنده , , Carolyn Foster، نويسنده , , Matthew Bryant، نويسنده , , Janice Lau، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1544
To page
1548
Abstract
The design, synthesis, and SAR studies of a structurally novel series of highly potent thrombin receptor (PAR-1) antagonists are described. Compound 30 is a highly potent thrombin receptor antagonist (IC50 = 6.3 nM), a related compound 36 showing efficacy in a monkey ex vivo study.
Keywords
Quinoline , thrombin , receptor , Antagonist , PAR-1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796616
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