Title of article
Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor
Author/Authors
Yan Liu، نويسنده , , Yufang Xu، نويسنده , , Xuhong Qian، نويسنده , , Yi Xiao، نويسنده , , Jianwen Liu، نويسنده , , Liyun Shen، نويسنده , , Junhui Li، نويسنده , , Yuanxing Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1562
To page
1566
Abstract
Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A2 and A4 showed good hypoxic–oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.
Keywords
Fluorescent markers , synthesis , evaluation , Hypoxic cells , solid tumor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796620
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