Title of article :
Depeptidization efforts on α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity
Author/Authors :
Stéphane L. Bogen، نويسنده , , Sumei Ruan، نويسنده , , Rong Liu، نويسنده , , Sony Agrawal، نويسنده , , John Pichardo، نويسنده , , Andrew Prongay، نويسنده , , Bahige Baroudy، نويسنده , , Anil K. Saksena، نويسنده , , Viyyoor Girijavallabhan، نويسنده , , F. George Njoroge، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
7
From page :
1621
To page :
1627
Abstract :
Depeptidization efforts of the P3–P2 region of P3 capped α-ketoamide inhibitor of HCV NS3 serine protease 1 are reported. We clearly established that N-methylation of the P2 nitrogen and modification of the carboxylic acid terminus were essential for activity in the replicon assay.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2006
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
796632
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=796632
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