Title of article
Biological studies of photoinducible phenol quaternary ammonium derivatives
Author/Authors
Yang Song، نويسنده , , Ping Wang، نويسنده , , Juanjuan Wu، نويسنده , , Xiang Zhou، نويسنده , , Xiao-Lian Zhang، نويسنده , , Linhong Weng، نويسنده , , Xiaoping Cao، نويسنده , , Feng Liang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1660
To page
1664
Abstract
Three water-soluble DNA cross-linking phenol quaternary ammonium derivatives 3, 4, and 5 could inhibit the transcription in vitro by photoactivation. DNA interstrand cross-linking action might be the key factor to inhibit transcription by these compounds. Further tumor cell apoptosis was observed by flow cytometry it indicated that cross-linking agent 5 could significantly induce the late apoptosis of tumor cells.
Keywords
Photoinducible , Apoptosis , DNA cross-linking agent , Interstrand
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796640
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