Title of article
Design and synthesis of potent and subtype-selective PPARα agonists
Author/Authors
Ranjit C. Desai، نويسنده , , Edward Metzger، نويسنده , , Conrad Santini، نويسنده , , Peter T. Meinke، نويسنده , , James V. Heck، نويسنده , , Joel P. Berger، نويسنده , , Karen L. MacNaul، نويسنده , , Tian-Quan Cai، نويسنده , , Samuel D. Wright، نويسنده , , Arun Agrawal، نويسنده , , David E. Moller، نويسنده , , Soumya P. Sahoo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
1673
To page
1678
Abstract
Beginning with a moderately potent PPARγ agonist 9, a series of potent and highly subtype-selective PPARα agonists was identified through a systematic SAR study. Based on the results of the efficacy studies in the hamster and dog models of dyslipidemia and the desired pharmacokinetic data, the optimized compound 39 was selected for further profiling.
Keywords
PPAR? agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796643
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