Author/Authors :
Marco Franceschin، نويسنده , , Luigi Rossetti، نويسنده , , Anna D’Ambrosio، نويسنده , , Stefano Schirripa، نويسنده , , Armandodoriano Bianco، نويسنده , , Giancarlo Ortaggi، نويسنده , , Maria Savino، نويسنده , , Christoph Schultes، نويسنده , , Stephen Neidle، نويسنده ,
Abstract :
The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding.
Keywords :
G-Quadruplex , telomerase , Alkaloid , Berberine
