Author/Authors :
Jeremy L. Clark، نويسنده , , J. Christian Mason، نويسنده , , Laurent Hollecker، نويسنده , , Lieven J. Stuyver، نويسنده , , Phillip M. Tharnish، نويسنده , , Tamara R. McBrayer، نويسنده , , Michael J. Otto، نويسنده , , Phillip A. Furman، نويسنده , , Raymond F. Schinazi، نويسنده , , Kyoichi A. Watanabe، نويسنده ,
Abstract :
A series of purine nucleosides containing the 2′-deoxy-2′-fluoro-2′-C-methylribofuranosyl moiety were synthesized and evaluated as potential inhibitors of the hepatitis C virus in vitro. Of the nucleosides that were synthesized, only those possessing a 2-amino group on the purine base reduced the levels of HCV RNA in a subgenomic replicon assay.
Keywords :
nucleosides , purines , hepatitis C , HCV
