Title of article
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode
Author/Authors
Thomas W. von Geldern، نويسنده , , Chunqiu Lai، نويسنده , , Rebecca J. Gum، نويسنده , , Melissa Daly، نويسنده , , Chaohong Sun، نويسنده , , Elizabeth H. Fry، نويسنده , , Celerino Abad-Zapatero، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1811
To page
1815
Abstract
We have identified benzoxazole benzenesulfonamide 1 as a novel allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). X-ray crystallographic and biological studies of 1 indicate a distinct binding mode that recapitulates features of several previously reported FBPase-1 inhibitor classes.
Keywords
Benzoxazole benzenesulfonamides , allosteric regulation , X-ray crystallography , Enzyme inhibitor , 6-bisphosphatase , fructose-1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796669
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