Title of article
Synthesis of constrained ceramide analogs and their potent antileukemic activities
Author/Authors
Hyun-Joon Ha، نويسنده , , Myeng Chan Hong، نويسنده , , Seung Whan Ko، نويسنده , , Yong Woo Kim، نويسنده , , Won Koo Lee، نويسنده , , Jungchan Park، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1880
To page
1883
Abstract
Constrained ceramide analogs were designed and synthesized by binding terminal alcohol and amine of ceramide with additional carbonyl functional group as 3-acetyl (3), 3-propionyl (4), 3-benzoyl (5), and 3-hexadecanoyl-4-(1-hydroxyhexadec-2-enyl)-oxazolidin-2-ones (6). Compounds 4 and 5 showed potent antileukemic activities against human leukemia HL-60 cells with good correlation between cell death and DNA fragmentation.
Keywords
Apoptosis , constrained , Antileukemic , Analogs , Ceramide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796683
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