Author/Authors :
Weigang Huang، نويسنده , , Jingya Li، نويسنده , , Wei Zhang، نويسنده , , Yueyang Zhou، نويسنده , , Chuanming Xie، نويسنده , , Yu Luo، نويسنده , , Yunfei Li، نويسنده , , Jingli Wang، نويسنده , , Jia Li، نويسنده , , Wei Lu، نويسنده ,
Abstract :
Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC50 values in the micromolar range.
