Title of article
Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases
Author/Authors
Weigang Huang، نويسنده , , Jingya Li، نويسنده , , Wei Zhang، نويسنده , , Yueyang Zhou، نويسنده , , Chuanming Xie، نويسنده , , Yu Luo، نويسنده , , Yunfei Li، نويسنده , , Jingli Wang، نويسنده , , Jia Li، نويسنده , , Wei Lu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1905
To page
1908
Abstract
Miltirone analogues were synthesized and evaluated for inhibitory activity against Cdc25 and PTP1B. Most of the compounds demonstrated potent Cdc25 inhibitory activity, and several exhibited higher selectivity for Cdc25 than for PTP1B. In a cytotoxic assay, most of the compounds displayed cytotoxicity against the tumor cell lines A549 and HCT-116, producing IC50 values in the micromolar range.
Keywords
Miltirone , cancer , Cdc25 phosphatases
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796688
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