Title of article
Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides
Author/Authors
Eugene B. Grant، نويسنده , , Deodialsingh Guiadeen، نويسنده , , Darren Abbanat، نويسنده , , Barbara D. Foleno، نويسنده , , Karen Bush and Osnat Herzberg، نويسنده , , Mark J. Macielag، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1929
To page
1933
Abstract
A new series of erythromycin A derivatives, the 6-O-heteroarylcarbamoyl-11,12-lactoketolides, with activity against macrolide-resistant streptococci, are described. Structurally, these macrolide antibiotics are characterized by a heteroaryl side chain attached to the macrolactone core through a carbamate linkage at the C6 position, as well as 11,12-γ-lactone and 3-keto functionalities. The synthesis and antibacterial activity of this new series of ketolides are discussed.
Keywords
Antibacterail activity , Ketolide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796693
Link To Document