Title of article
Fluorescent non-imidazole histamine H3 receptor ligands with nanomolar affinities
Author/Authors
Michael Amon، نويسنده , , Xavier Ligneau، نويسنده , , Jean Charles Schwartz، نويسنده , , Holger Stark، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
1938
To page
1940
Abstract
ω-Piperidinoalkanamine derivatives with fluorescent moieties (2-cyanoisoindol-1-yl, 7-nitrobenzofurazan-4-yl) have been synthesized starting from piperidine in three steps. The compounds display moderate to good histamine hH3 receptor affinities with Ki values ranging from 178 to 11 nM. The new compounds may act as tools for identification and understanding of the binding site on the histamine H3 receptor.
Keywords
histamine , Antagonist , ligand , H3 , medicinal chemistry , fluorescence
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796695
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