Author/Authors :
Ian T. Huscroft، نويسنده , , Emma J. Carlson، نويسنده , , Gary G. Chicchi، نويسنده , , Marc M. Kurtz، نويسنده , , Clare London، نويسنده , , Piotr Raubo، نويسنده , , Alan Wheeldon، نويسنده , , Janusz J. Kulagowski، نويسنده ,
Abstract :
1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK1 receptor antagonists. Substitution at the 6-exo-position led to high affinity NK1 antagonists with a prolonged duration of action in vivo. Incorporation of an α-methyl substituent in the pendent benzyl ether side chain gave compounds with increased selectivity over the hERG channel.
