Title of article
1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK1) antagonists
Author/Authors
Ian T. Huscroft، نويسنده , , Emma J. Carlson، نويسنده , , Gary G. Chicchi، نويسنده , , Marc M. Kurtz، نويسنده , , Clare London، نويسنده , , Piotr Raubo، نويسنده , , Alan Wheeldon، نويسنده , , Janusz J. Kulagowski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2008
To page
2012
Abstract
1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK1 receptor antagonists. Substitution at the 6-exo-position led to high affinity NK1 antagonists with a prolonged duration of action in vivo. Incorporation of an α-methyl substituent in the pendent benzyl ether side chain gave compounds with increased selectivity over the hERG channel.
Keywords
NK1 receptor antagonist , Drug design and synthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796711
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