Title of article
Small molecule inhibitors of plasma kallikrein
Author/Authors
Wendy B. Young، نويسنده , , Roopa Rai، نويسنده , , William D. Shrader، نويسنده , , Jana Burgess-Henry، نويسنده , , Huiyong Hu، نويسنده , , Kyle C. Elrod، نويسنده , , Paul A. Sprengeler، نويسنده , , Mary E. McGrath and Bradley A. Katz، نويسنده , , Juthamas Sukbuntherng، نويسنده , , Joyce Mordenti، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
2034
To page
2036
Abstract
Plasma kallikrein is a serine protease that is involved in pathways of inflammation, complement fixation, coagulation, and fibrinolysis. Herein, we describe the SAR and structural binding modes of a series of inhibitors of plasma kallikrein as well as the pharmacokinetics of a lead analog 11 in rat.
Keywords
Plasma kallikrein , p-kallikrein , Serine protease , coagulation , fibrinolysis , Kinin generation , Small molecule inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796717
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