Title of article
Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I
Author/Authors
Tao Jiang، نويسنده , , Kelli L. Kuhen، نويسنده , , Karen Wolff، نويسنده , , Hong-Yin Chen، نويسنده , , Kimberly Bieza، نويسنده , , Jeremy Caldwell، نويسنده , , Badry Bursulaya، نويسنده , , Tom Yao-Hsing Wu، نويسنده , , Yun He، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2105
To page
2108
Abstract
A novel oxindole was discovered as an HIV non-nucleoside reverse transcriptase inhibitor via HTS using a cell-based assay. Systematic structural modifications were carried out to establish its SAR. These modifications led to the identification of oxindoles with low nanomolar potency for inhibiting HIV replication. These novel and potent oxindoles could serve as advanced leads for further optimizations.
Keywords
AIDS , HIV , reverse transcriptase , inhibitor , Oxindole , SAR
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796729
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