Title of article
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1
Author/Authors
Ha-soon Choi، نويسنده , , Zhicheng Wang، نويسنده , , Wendy Richmond، نويسنده , , Xiaohui He، نويسنده , , Kunyong Yang، نويسنده , , Tao Jiang، نويسنده , , Taebo Sim، نويسنده , , Donald Karanewsky، نويسنده , , Xiang-ju Gu، نويسنده , , Vicki Zhou، نويسنده , , Yi Liu، نويسنده , , Osamu Ohmori، نويسنده , , Jeremy Caldwell، نويسنده , , Nathanael Gray، نويسنده , , Yun He، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2173
To page
2176
Abstract
A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to target focal adhesion kinase (FAK). A number of these pyrrolopyrimides exhibited low micromolar inhibitory activities against focal adhesion kinase, and their preliminary SAR was established via systematic chemical modifications. The 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines represent a new class of kinase inhibitors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796744
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