Title of article
Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (−)-dysiherbaine
Author/Authors
Jamie L. Cohen، نويسنده , , Agenor Limon، نويسنده , , Ricardo Miledi، نويسنده , , A. Richard Chamberlin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
2189
To page
2194
Abstract
The design and synthesis of four 2,2-disubstituted dihydrobenzofurans that are structurally related to several glutamate-containing natural products, including (−)-dysiherbaine, is described. Biological evaluation of these analogs shows that one is a KA receptor antagonist and another is an NMDA receptor agonist.
Keywords
KA receptor agonist , KA reeptor antagonist , Dysiherbaine , NMDA receptor agonist , Scaffold , Excitatory amino acid receptors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796747
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