Title of article
The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors
Author/Authors
Cheryl A. Grice، نويسنده , , Kevin Tays، نويسنده , , Haripada Khatuya، نويسنده , , Darin J. Gustin، نويسنده , , Christopher R. Butler، نويسنده , , Jianmei Wei، نويسنده , , Clark A. Sehon، نويسنده , , Siquan Sun، نويسنده , , Yin Gu، نويسنده , , Wen Jiang، نويسنده , , Robin L. Thurmond، نويسنده , , Lars Karlsson، نويسنده , , James P. Edwards، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2209
To page
2212
Abstract
A series of competitive, reversible cathepsin S (CatS) inhibitors was investigated. An earlier disclosure detailed the discovery of the 4-(2-keto-1-benzimidazolinyl)-piperidin-1-yl moiety as an effective replacement for the 4-arylpiperazin-1-yl group found in our screening hit. Continued investigation into replacements for the 4-aryl piperazine resulted in the identification of potentially useful CatS inhibitors with enzymatic and cellular activity similar to that of JNJ 10329670 as disclosed in a previous publication.
Keywords
Cathepsin S , Cysteine protease inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796751
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