Title of article
Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands
Author/Authors
Mingzhang Gao، نويسنده , , Deyuan Kong، نويسنده , , Abraham Clearfield، نويسنده , , Qi-Huang Zheng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2229
To page
2233
Abstract
New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid) receptor ligands to image brain diseases. The single crystal structure of the most potent compound N-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (5a) is first reported.
Keywords
2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptor , Brain diseases , 2 , 4-tetrahydroisoquinoline derivatives , 3 , Fluorine-18 , 7-dimethoxy-1 , positron emission tomography , N-Acetyl-1-aryl-6 , Carbon-11
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796755
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