Title of article
Design and structure–activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases
Author/Authors
Kelly Frazier، نويسنده , , Elisa Jazan، نويسنده , , Christopher M. McBride، نويسنده , , Sabina Pecchi، نويسنده , , Paul A. Renhowe، نويسنده , , Cynthia M. Shafer، نويسنده , , Clarke Taylor، نويسنده , , Dirksen Bussiere، نويسنده , , Molly Min He، نويسنده , , Johanna M. Jansen، نويسنده , , Gena Lapointe، نويسنده , , Sylvia Ma، نويسنده , , Jayesh Vora، نويسنده , , Marion Wiesmann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2247
To page
2251
Abstract
Herein are described a series of novel heterocyclic analogs of the 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one scaffold. These compounds are potent inhibitors of receptor tyrosine kinases and exhibit favorable pharmacokinetic profiles. The synthesis and SAR of these compounds are described.
Keywords
Basic fibroblast growth factor (bFGF) , Platelet derived growth factor (PDGF) , Vascular endothelial growth factor (VEGF)
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796759
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