Title of article
Structure–activity relationship of thiopyrimidines as mGluR5 antagonists
Author/Authors
Lance G. Hammerland، نويسنده , , Martin Johansson، نويسنده , , Jonas Malmstr?m، نويسنده , , Jan P. Mattsson، نويسنده , , Alexander B.E. Minidis، نويسنده , , Karolina Nilsson، نويسنده , , Alecia Peterson، نويسنده , , David Wensbo، نويسنده , , Andreas W?llberg، نويسنده , , Krister ?sterlund، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
2467
To page
2469
Abstract
Structure–activity relationship investigations of the thiopyrimidine (1), an HTS hit with micromolar activity as a metabotropic glutamate receptor 5 (mGluR5) antagonist, led to compounds with sub-micromolar activity.
Keywords
Metabotropic Glutamate Receptor , mGluR5 , Thiopyrimidine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796803
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